雌激素与骨关节炎.

Estrogen is closely associated with osteoarthritis. Osteoarthritis (OA) is a disease of systemic arthritis mainly involving cartilage and subchondral bone. Estrogen and its receptors affect the metabolism or apoptosis of articular cartilage and subchondral bone, and could directly or indirectly affect the occurrence and development of osteoarthritis process through a variety of ways. Based on recent literature from China and overseas, estrogen has multiple-level close relationship with OA at three aspects epidemiology, clinical and experimental studies. There are differences among the specific correlations, however, the majority of studies have suggested that the deficiency of E2 can damage the cartilage, and almost all of the animal experiments have suggested that E2 is directly or indirectly associated with OA. In particular clinical studies have suggested the clinical application of E2 replacement therapy. E2 or its regulators can effectively relieve pain in patients with OA, and slightly reduce the prevalence rate and reduce the incidence rate of joint replacement. We consider that combining the latest progress on OA pathogenesis with the recognition of the relationship between OA and E2, from the aspects of molecular immunology and biomechanics to understand the associations of E2 with induced local inflammatory or destruction of bone and cartilage metabolism, as a research approach to OA will contribute to a better understanding of the mechanism, which will be constructive to the development of drugs for specific targets. In this paper, we reviewed the latest progress in the study of estrogen and osteoarthritis in three aspects: epidemiology, clinical and experimental research. [ABSTRACT FROM AUTHOR]