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Pannexin1 Single Nucleotide Polymorphism and Platelet Reactivity in a Cohort of Cardiovascular Patients.
- Source :
-
Cell Communication & Adhesion . 2017, Vol. 23 Issue 1, p11-15. 5p. 3 Charts. - Publication Year :
- 2017
-
Abstract
- Pannexin1 (Panx1), a membrane channel-forming protein permitting the passage of small-sized molecules, such as ATP, is expressed in human platelets. Recently, we showed that inhibiting Panx1 affects collagen-induced platelet aggregation but not aggregation triggered by other agonists. We also found that a single nucleotide polymorphism (SNP; rs1138800) in thePanx1gene encoded for a gain-of-function channel (Panx1-400C)and was associated with enhanced collagen-induced platelet reactivity. Here, we assessed the association of this SNP with platelet reactivity in a cohort of 758 stable cardiovascular patients from the ADRIE study treated with aspirin and/or clopidogrel. We found that presence of thePanx1-400Callele was not associated with platelet reactivity in stable cardiovascular patients, irrespective of the platelet aggregation agonist used (collagen, ADP or arachidonic acid) or the anti-platelet drug regimen. Moreover, thePanx1-400A > CSNP did also not affect the re-occurrence of cardiac ischemic events in the same stable cardiovascular patient cohort. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 15419061
- Volume :
- 23
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cell Communication & Adhesion
- Publication Type :
- Academic Journal
- Accession number :
- 126975379
- Full Text :
- https://doi.org/10.1080/15419061.2017.1282469