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Alginate/Chitosan Compact Polyelectrolyte Complexes: A Cell and Bacterial Repellent Material.
- Source :
-
Chemistry of Materials . 12/26/2017, Vol. 29 Issue 24, p10418-10425. 8p. - Publication Year :
- 2017
-
Abstract
- Ultracentrifugated compact polyelectrolyte complexes (uCoPECs) represent a new class of materials that are obtained by ultracentrifugation of solutions of polyanion/polycation complexes in the presence of salt. In the present study, two polysaccharides, chitosan and alginate, were used to form such complexes, thus providing a solid material uniquely composed of polysaccharides. The conditions for obtaining the uCoPEC material were optimized: the optimal salt concentration and polysaccharide concentrations were assessed, and the ultracentrifugation speed proved to be a key parameter to obtain compact and homogeneous materials. The Young's modulus, E, of the material was of the order of 12 MPa, which is the highest E value measured for a uCoPEC. The material contained nanometer-sized crystals of chitosan as indicated by X-ray diffraction. Most strikingly, this material proves to be totally cell- and bacteria-resistant. Immunological tests show that this uCoPEC does not induce any proinflammatory response. This makes it a suitable candidate for the development of biocompatible and antifouling biomaterials composed only of polysaccharides. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08974756
- Volume :
- 29
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Chemistry of Materials
- Publication Type :
- Academic Journal
- Accession number :
- 126974355
- Full Text :
- https://doi.org/10.1021/acs.chemmater.7b03863