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Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities.
- Source :
-
Fitoterapia . Jan2018, Vol. 124, p206-210. 5p. - Publication Year :
- 2018
-
Abstract
- Four new naphthoquinones ( 1 – 4 ), named rhinacanthins S ( 1 ), T ( 2 ), U ( 3 ) and V ( 4 ), together with 13 known naphthoquinones were isolated from the leaf extract of Rhinacanthus nasutus . The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy and mass spectrometry. Rhinacanthin S ( 1 ) exhibited acetylcholinesterase inhibition activity with a % inhibition value of 48.04 ± 3.25. The known rhinacanthin A ( 5 ) showed cytotoxicity against a MCF-7 cell line with an IC 50 value of 8.79 μM, while rhinacanthin N ( 15 ) was active against the NCI-H187 cell line with an IC 50 = 2.24 μM and Vero cells (IC 50 = 3.00 μM) [ABSTRACT FROM AUTHOR]
- Subjects :
- *LUNG tumors
*ALTERNATIVE medicine
*ANTINEOPLASTIC agents
*BIOLOGICAL models
*CHOLINESTERASE inhibitors
*DOSE-effect relationship in pharmacology
*LEAVES
*MASS spectrometry
*MEDICINAL plants
*NUCLEAR magnetic resonance spectroscopy
*SPECTRUM analysis
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
*PREVENTION
BREAST tumor prevention
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 124
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 126946247
- Full Text :
- https://doi.org/10.1016/j.fitote.2017.11.011