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Decreased expression of interleukin-37 in the ectopic and eutopic endometria of patients with adenomyosis.

Authors :
Jiang, Jian Fa
Xiao, Song Shu
Xue, Min
Source :
Gynecological Endocrinology. Jan2018, Vol. 34 Issue 1, p83-86. 4p.
Publication Year :
2018

Abstract

Previous studies have shown that alterations of cytokines might play a role in the pathogenesis of adenomyosis. This study aims to investigate the expression of interleukin-37 (IL-37), an anti-inflammatory cytokine, in the eutopic and ectopic endometria of patients with adenomyosis. Endometrial specimens were collected from 30 women with adenomyosis and 20 without adenomyosis. The gene and protein expression of IL-37 was measured using a quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. Compared with the control endometria, the protein expression level and gene level of IL-37 was significantly lower in both the ectopic and eutopic endometria of patients with adenomyosis. The gene and protein expressions of IL-37 in ectopic endometria were lower than those in eutopic endometria of patients with adenomyosis. Our results suggest that there was a low level of IL-37 in the eutopic and ectopic endometria of patients with adenomyosis, and an abnormal inflammatory response might occur in the endometria of patients with adenomyosis. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
09513590
Volume :
34
Issue :
1
Database :
Academic Search Index
Journal :
Gynecological Endocrinology
Publication Type :
Academic Journal
Accession number :
126920288
Full Text :
https://doi.org/10.1080/09513590.2017.1354367