Back to Search
Start Over
Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway.
- Source :
-
Rejuvenation Research . Dec2017, Vol. 20 Issue 6, p462-472. 11p. - Publication Year :
- 2017
-
Abstract
- In this study, we evaluated the protective effects of naringenin on aging mice induced by d-galactose (d-gal). Open field test and Morris water maze test were performed to evaluate the effect of naringenin on behavioral dysfunction. Hematoxylin-eosin staining, TUNEL staining, and Nissl staining were used to estimate the effect of naringenin on neurological deficits. Furthermore, naringenin markedly activated PI3K/Akt signaling, eventually promoted the nuclear translocation of nuclear factor-erythroid 2-related factor 2, and induced the expression of heme oxygenase 1 and NAD(P)H-quinone oxidoreductase 1. Superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid reactive substances (TBARS) assays were conducted to evaluate oxidative stress in d-gal-induced aging mice. Our finding demonstrated that naringenin was a promising agent for attenuating the aging process, and enhancing endogenous antioxidant defense capacity was a reliable strategy to delay the senescence process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NARINGENIN
*BEHAVIOR disorders
*NEUROLOGICAL disorders
*LABORATORY mice
*PROTEIN kinase B
*OXIDATIVE stress
*GALACTOSE
*PROTEIN metabolism
*AGING
*ANIMAL behavior
*ANIMAL experimentation
*ANTHROPOMETRY
*APOPTOSIS
*BIOLOGICAL models
*BODY weight
*BRAIN
*CELLULAR signal transduction
*MEMORY
*MICE
*MOLECULAR structure
*MOTOR ability
*NEURONS
*OXIDATION-reduction reaction
*PHOSPHOTRANSFERASES
*SPATIAL behavior
*TRANSFERASES
*HEXOSES
*FLAVANONES
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 15491684
- Volume :
- 20
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Rejuvenation Research
- Publication Type :
- Academic Journal
- Accession number :
- 126828498
- Full Text :
- https://doi.org/10.1089/rej.2017.1960