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Pharmacological management of gastroesophageal reflux disease in infants: current opinions.
- Source :
-
Current Opinion in Pharmacology . Dec2017, Vol. 37, p112-117. 6p. - Publication Year :
- 2017
-
Abstract
- Gastroesophageal reflux disease (GERD) constitutes a troublesome symptom complex resulting from retrograde passage of gastric contents into the esophagus or extra-esophageal regions. Premature-born, high-risk infants and those with neuro-aero-digestive pathologies are at increased risk. Critical review over the last 3 years was conducted, and current opinions on pharmacological targets include agents aimed at prevention of transient lower esophageal sphincter relaxation, modification of the physico-chemical composition of gastric contents, modification of gut motility, or altering sensory thresholds to ameliorate the troublesome symptoms. As data from well-designed studies is limited in the infant population, information from adult studies has been cited where potential application may be helpful. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14714892
- Volume :
- 37
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 126635947
- Full Text :
- https://doi.org/10.1016/j.coph.2017.10.013