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Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population.
- Source :
-
Fertility & Sterility . Dec2017, Vol. 108 Issue 6, p1056-1056. 1p. - Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>To investigate the associations between genetically cis-regulated gene expression levels and nonobstructive azoospermia (NOA) susceptibility.<bold>Design: </bold>Transcriptome-wide association study (TWAS).<bold>Setting: </bold>Medical university.<bold>Interventions: </bold>None.<bold>Main Outcome Measure(s): </bold>The cis-hg2 values for each gene were estimated with GCTA software. The effect sizes of cis-single-nucleotide polymorphisms (SNPs) on gene expression were measured using GEMMA software. Gene expression levels were entered into our existing NOA GWAS cohort using GEMMA software. The TWAS P-values were calculated using logistic regression models.<bold>Result(s): </bold>Expression levels of 1,296 cis-heritable genes were entered into our existing NOA GWAS data. The TWAS results identified two novel genes as statistically significantly associated with NOA susceptibility: PILRA and ZNF676. In addition, 6p21.32, previously reported in NOA GWAS, was further validated to be a susceptible region to NOA risk.<bold>Conclusion(s): </bold>Analysis with TWAS provides fruitful targets for follow-up functional studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASIANS
*CELL receptors
*DATABASES
*DISEASE susceptibility
*FERTILITY
*GENETIC polymorphisms
*GENETIC techniques
*INFERTILITY
*PHENOTYPES
*DNA-binding proteins
*LOGISTIC regression analysis
*BIOINFORMATICS
*CASE-control method
*MEMBRANE glycoproteins
*GENE expression profiling
*ODDS ratio
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 108
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 126618152
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2017.09.023