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Systematic review and meta-analysis of liver transplantation using grafts from deceased donors aged over 70 years.

Authors :
Dasari, Bobby V.
Mergental, Hynek
Isaac, John R.
Muiesan, Paolo
Mirza, Darius F.
Perera, Thamara
Source :
Clinical Transplantation. Dec2017, Vol. 31 Issue 12, pn/a-N.PAG. 9p.
Publication Year :
2017

Abstract

Introduction Due to the current organ shortage, nearly 20% of patients die waiting for a liver transplant ( LT). The average donor age is on the rise, and grafts from elderly donors are offered as extended criteria grafts. Methods This is a meta-analysis comparing the outcome differences of adult patients undergoing LT using grafts from <70-year-old donors vs >70-year-old donors. The primary end-points were graft and patient survival. Secondary outcomes were biliary and vascular complications as well as graft function. The odds ratio ( OR) is a summary statistic with the corresponding 95% confidence interval; P < .05 was considered to be statistically significant. Results Eight nonrandomized comparative studies with 4376 LT recipients were included. About 79.9% and 20.1% of the grafts were from <70-year-old and >70-year-old donors, respectively. Graft survival at 1 year was similar between the two groups ( P = .11), but there was better 3-year and 5-year graft survival in the >70-year-old group ( P = .006 and P < .0001, respectively). Patient survival was also similar between the groups at 1 year ( P = .54), but with better survival at 3-year and 5-year follow-ups ( P = .007 and P < .0001, respectively) in the >70-year-old group. There were no statistically significant differences in the incidence of biliary, vascular, and graft functional-related complications. Conclusion Liver grafts from selected >70-year-old donors do not pose added organ-specific risks and thus have comparable transplantation outcomes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09020063
Volume :
31
Issue :
12
Database :
Academic Search Index
Journal :
Clinical Transplantation
Publication Type :
Academic Journal
Accession number :
126586838
Full Text :
https://doi.org/10.1111/ctr.13139