Back to Search
Start Over
Coupling astogenic aging in the colonial tunicate Botryllus schlosseri with the stress protein mortalin.
- Source :
-
Developmental Biology . Jan2018, Vol. 433 Issue 1, p33-46. 14p. - Publication Year :
- 2018
-
Abstract
- Botryllus schlosseri , a colonial marine invertebrate, exhibits three generations of short-lived astogenic modules that continuously grow and die throughout the colony's entire lifespan, within week-long repeating budding cycles (blastogenesis), each consisting of four stages (A-D). At stage D, aging is followed by the complete absorption of adult modules (zooids) via a massive apoptotic process. Here we studied in Botryllus the protein mortalin (HSP70s member), a molecule largely known for its association with aging and proliferation. In-situ hybridization and qPCR assays reveal that mortalin follows the cyclic pattern of blastogenesis. Colonies at blastogenic stage D display the highest mortalin levels, and young modules exhibit elevated mortalin levels compared to old modules. Manipulations of mortalin with the specific allosteric inhibitor MKT-077 has led to a decrease in the modules’ growth rate and the development of abnormal somatic/germinal morphologies (primarily in vasculature and in organs such as the endostyle, the stomach and gonads). We therefore propose that mortalin plays a significant role in the astogeny and aging of colonial modules in B. schlosseri, by direct involvement in the regulation of blastogenesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00121606
- Volume :
- 433
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 126559345
- Full Text :
- https://doi.org/10.1016/j.ydbio.2017.10.023