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Long-Term Metabolic Effects in French-Canadian Children and Adolescents Treated with Second-Generation Antipsychotics in Monotherapy or Polytherapy: A 24-Month Descriptive Retrospective Study: Effets métaboliques à long terme chez des enfants et des adolescents canadiens-français d’un traitement par antipsychotiques de deuxième génération en monothérapie ou polythérapie: une étude descriptive rétrospective de 24 mois
- Source :
-
Canadian Journal of Psychiatry . Dec2017, Vol. 62 Issue 12, p827-836. 10p. 1 Diagram, 3 Charts. - Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>To compare weight and glucose changes of long-term second-generation antipsychotic (SGA) monotherapy versus polytherapy (switching or combining SGAs) in children and adolescents.<bold>Methods: </bold>This is a 24-month retrospective study conducted between November 2005 and June 2013. From 147 antipsychotic-naive patients selected (mean age, 12.8 years; 95% confidence interval [CI], 9.8-15.9), 116 (78.9%) received SGA monotherapy and 31 (21.1%) SGA polytherapy for up to 24 months. Height, weight, and fasting glucose (FG) were measured at baseline and 1, 3, 6, 12, and 24 months. Linear mixed-model analysis was used to compare weight, body mass index z score (BMI z score), and glucose changes between the 2 SGA treatment groups, with the repeated factor being the time relative to baseline at 1, 3, 6, 12, and 24 months.<bold>Results: </bold>Overall, after 24 months of SGA treatment, mean weight increased significantly by 12.8 kg (95% CI, 10.4-15.0), BMI z score by 0.44 (95% CI, 0.21-0.68), and FG levels by 0.29 mmol/L (95% CI, 0.11-0.47). Incidence of overweight/obesity was 22.6%, BMI z score increase over 0.5 was 9.4%, impaired fasting glucose was 9.4%, and type 2 diabetes mellitus was 3.1%. Regarding metabolic effects, no significant difference was found between the subjects taking a single SGA and those exposed to an SGA polytherapy.<bold>Conclusion: </bold>Our study confirms the significant increase of metabolic complications during 24 months of SGA treatment without excluding or confirming a difference between the 2 groups of treatment (mono vs. poly). [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIPSYCHOTIC agents
*DRUG side effects
*METABOLISM
*MEDICATION therapy management
*PEDIATRIC drug therapy
*CHILD psychiatry
*WEIGHT gain
*MENTAL illness drug therapy
*PSYCHIATRIC epidemiology
*OBESITY
*COMBINATION drug therapy
*FRENCH-Canadians
*BLOOD sugar
*RETROSPECTIVE studies
*TYPE 2 diabetes
*BODY mass index
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 07067437
- Volume :
- 62
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Canadian Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 126546743
- Full Text :
- https://doi.org/10.1177/0706743717718166