SYNTHESIS OF MONO AND DI DIGOXIGENIN AND STROPHANTHIDIN CARDIAC GLYCOSIDES.

Cardiac glycosides are the efficacious groups of naturally occurring compounds that influences the vital blood pumping mechanism. They are constituted of two parts i.e. steroidal aglycon part and the glycon. The glycon part may contain a monosaccharide or di to oligosaccharide. In this present paper we have made glycosyl donars of glucose, mannose, galactose and gentiobiose a disaccharide, glycosyl donars of these mono and disaccaharide were prepared, further they were glycosidically linked to two cardenolides i.e. digoxigenin and strophanthidin by TMS-OTF method. The structure of synthetically prepared six monoglycosides and two diglycosides of digoxigenin and strophanthidin were confirmed by 1HNMR. [ABSTRACT FROM AUTHOR]