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The effect of Zataria multiflora and carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients.

Authors :
Alavinezhad, Azam
Hedayati, Mahdiyeh
Boskabady, Mohammad Hossein
Source :
Avicenna Journal of Phytomedicine. Nov/Dec2017, Vol. 7 Issue 6, p531-541. 11p.
Publication Year :
2017

Abstract

Objective: The preventive effect of Zataria multiflora in animal models of asthma has been reported. In the present study, its effect on wheezing, forced expiratory volume in 1 second, and plasma nitrite (NO2-) in asthmatic patients was studied. Materials and Methods: In this study, forty asthmatic patients including 15 males and 25 females (aged 45.8±6.21 years) were randomly allocated in four groups including placebo group (P), and three treatment groups which received two doses of Z. multiflora (groups Z low and Z high that received 5 and 10 mg/kg/day, respectively) and carvacrol (group C treated with 1.2 mg/kg/day). All patients were treated for two months in a double-blind manner. At three time points (before starting the treatment (pretreatment), and one and two month after treatment), wheezing during day and exercise, forced expiratory volume in 1 second and NO2- were measured. Results: Day wheeze and exercise wheeze were significantly reduced in treated groups with carvacrol and both doses of Z. multiflora compared to pretreatment (p<0.05 to p<0.01). However, FEV1% was significantly increased in treated groups with carvacrol and both doses of Z. multiflora (p<0.05 to p<0.001). Plasma level of NO2- was also significantly decreased in Z high and carvacrol groups after two months of treatment (p<0.01 to p<0.001). However, most of evaluated parameters in placebo group did not show significant changes during the study. Conclusion: Z. multiflora and its constituent, carvacrol, improved FEV1% while reduced wheezing and plasma level of NO2- in asthmatic patients. Therefore, a possible therapeutic potential for this plant and its constituent, carvacrol could be suggested to be used against asthma. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22287930
Volume :
7
Issue :
6
Database :
Academic Search Index
Journal :
Avicenna Journal of Phytomedicine
Publication Type :
Academic Journal
Accession number :
126495752