舒血宁注射液联合布地耐德对 COPD 急性加重期患者血清 MMP-9, IL-6, IL-8, TNF-α 及肺功能的影响

Objective: To investigate the influence of shuxuening injection combined with budesonide on the serum levels of matrix metalloproteinases-9（MMP-9） and interleukin-6（IL-6）, interleukin-8（IL-8）, tumor necrosis factor-α（TNF-α） and lung function of chronic obstructive pulmonary disease（COPD） patients with acute aggravating period. Methods: 112 cases of COPD patients with acute aggravating period were divided into the control group and the observation group with 56 cases in each group. The control group was treated by budesonide, while the observation group was treated based on the control group combined with Shuxuening injection. The total effective rate, serum levels of MMP-9, IL-6, IL-8, TNF-α, propylene glycol（MDA）, superoxide disproportionation alcohol（SOD）, CO2 partial pressure（PaCO2）, blood oxygen partial pressure（PaO2）, peak velocity of flow（PEF）, maximum mid expiratory gas flow velocity（MMEF）, forced vital capacity（FVC）, CD3+, CD4+, CD8+, CD4+/CD8+, and the occurrence of adverse reactions before and after the treatment were compared between two groups. Results: The total effective rate of observation group was higher than that of the control group（94.64% vs 80.35 %, P<0.05）. After the treatment, the serum levels of MMP-9, IL-6, IL-8, TNF-α, MDA, Pa CO2, CD8+of observation group were lower than those of the control group（P<0.05）. The serum levelof SOD, PaO2, PEF, MMEF, FVC, CD3+, CD4+,CD4+/CD8+of observation group were higher than those of the control group（P<0.05）. The occurrence of adverse reactions showed no difference between the two groups（P>0.05）. Conclusion: Shuxuening injection combined with budesonide was effective in the treatment of COPD patients with acute aggravating period, which could decrease the serum levels of MMP-9, IL-6, IL-8 and TNF-α, improve the lung function, reduce the oxidative stress and improve the arterial blood gas and immune function. [ABSTRACT FROM AUTHOR]