CNQX 在小鼠脑不同类型突触分泌中的作用.

Objective: To explore the role of 6-CYANO-2, 3-DIHYDROXY-7-NITROQUIN OXALINE (CNQX) in different types of synapse secretion. Methods: The spontaneous mEPSCs and eEPSCs at different extracellular concentrations of CNQX in cultured cortical or hippocampal neurons were recorded respectively. Results: The half inhibitory concentration (IC50) of CNQX in evoked neurotransmitter release was significantly higher than that of spontaneous release, indicating that the spontaneous neurotransmitter release was more sensitive to CNQX. No apparent difference was observed between cortical and hippocampal cells, suggesting that the blocking effect of CNQX was similar in different brain regions. Conclusion: CNQX might have differential regulating mechanisms between excitatory spontaneous and evoked neurotransmitter release,but without brain regions specificity. [ABSTRACT FROM AUTHOR]