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Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete.
- Source :
-
Organic Letters . 11/17/2017, Vol. 19 Issue 22, p6208-6211. 4p. - Publication Year :
- 2017
-
Abstract
- Two novel enediyne-derived natural products, amycolamycins A and B (1 and 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 126382329
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b03113