匹多莫德联合布地奈德雾化吸入对支气管哮喘患儿 IL-4, IFN-γ, 免疫球蛋白及T细胞亚群的影响

Objective: To investigate the influence of pidotimod combined with budesonide aerosol inhalation on the IL-4, IFN-γ,immunoglobulin and T cell subsets of children with bronchial asthma. Methods: 92 cases of children with bronchial asthma in our hospital from June 2015 to June 2016 were selected as the research objects and randomly divided into the observation group and the control group. The control group was given budesonide suspension treatment, and the observation group was treated by pidotimod oral liquid on the base of the control group. The changes of serum IgA, IgG, IgM, CD3+, CD4+, CD8+and CD4+/CD8+before and after treatment were detected and compared between the two groups. Results: Before treatment, there was no significant difference in the serum IL-4, IFN-γ,IgA, IgG, IgM, CD3+, CD4+, CD8+and CD4+/CD8+between two groups（P>0.05）. Compared with those before treatment, the serum level of IL-4 was significantly decreased, in the observation group, while the IFN-γ, IgA, IgG, IgM, CD3+, CD4+, CD4+/CD8+levels were significantly increased after treatment（P<0.05）. The IFN-γ, IgA, IgG, IgM, CD3+, CD4+, CD8+and CD4+/CD8+of control group showed no significant change before and after treatment（P>0.05）, only the serum IL-4 level was significantly decreased（P<0.05）. After treatment, the IL-4, IFN-γ, IgA, IgG, IgM, CD3+, CD4+, CD8+and CD4+/CD8+of observation group were better than those of the control group（P<0.05）.Conclusion: Compared with budesonide alone, pidotimod combined with budesonide could significantly regulate the immune function of children with bronchial asthma. [ABSTRACT FROM AUTHOR]