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Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.

Authors :
Xian‑jun Sun
Yan‑liang Li
Long‑gang Wang
Li‑qing Liu
Heng Ma
Wen‑hong Hou
Jin‑ming Yu
Source :
Oncology Letters. Dec2017, Vol. 14 Issue 6, p7283-7287. 5p. 1 Black and White Photograph, 2 Charts, 1 Graph.
Publication Year :
2017

Abstract

Microtubule‑associated serine/threonine kinase like (Mastl) is deregulated in a number of types of human malignancy and may be a kinase target for cancer treatment. The aim of the present study was to determine the Mastl expression in gastric cancer and to clarify its clinical and prognostic significance. Immunohistochemistry was performed on a cohort of 126 postoperative gastric cancer samples to detect the expression of Mastl and two epithelial to mesenchymal transition (EMT) markers, epithelial‑cadherin and Vimentin. The χ2 test, Kaplan‑Meier estimator analysis and Cox's regression model were used to analyze the data. Upregulated Mastl protein expression was observed in the gastric cancer tissues compared with that in the adjacent non‑cancerous gastric tissues. Increased Mastl expression was identified in 54/126 (42.9%) gastric cancer samples, and was significantly associated with lymph node metastasis, tumor relapse, EMT status and poor overall survival. Additional analysis demonstrated that the Mastl expression level stratified the patient outcome in stage III, but not stage II tumor subgroups. Cox's regression analysis revealed that increased Mastl expression was an independent prognostic factor for patients with gastric cancer. Mastl expression may be a valuable prognostic marker and a potential target for patients with gastric cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17921074
Volume :
14
Issue :
6
Database :
Academic Search Index
Journal :
Oncology Letters
Publication Type :
Academic Journal
Accession number :
126272180
Full Text :
https://doi.org/10.3892/ol.2017.7155