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Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions.
- Source :
-
Computational & Mathematical Methods in Medicine . 11/9/2017, p1-12. 12p. - Publication Year :
- 2017
-
Abstract
- Immunotherapy is one of the most recent approaches for controlling and curing malignant tumors. In this paper, we consider a mathematical model of periodically pulsed immunotherapy using CD4+ T cells and an antitumor cytokine. Mathematical analyses are performed to determine the threshold of a successful treatment. The interindividual variability is explored by one-, two-, and three-parameter bifurcation diagrams for a nontreatment case. Numerical simulation conducted in this paper shows that (i) the tumor can be regulated by administering CD4+ T cells alone in a patient with a strong immune system or who has been diagnosed at an early stage, (ii) immunotherapy with a large amount of an antitumor cytokine can boost the immune system to remit or even to suppress tumor cells completely, and (iii) through polytherapy the tumor can be kept at a smaller size with reduced dosages. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1748670X
- Database :
- Academic Search Index
- Journal :
- Computational & Mathematical Methods in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 126179368
- Full Text :
- https://doi.org/10.1155/2017/2906282