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Effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and endoplasmic reticulum stress of the cardiac muscle in obese middle-aged rats.
- Source :
-
Korean Journal of Physiology & Pharmacology . 2017, Vol. 21 Issue 6, p633-641. 9p. - Publication Year :
- 2017
-
Abstract
- The aim of this study is to investigate the effects of intermittent ladderclimbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks. Highfat diet and concurrent exercise resulted in no significant reduction in body weight but caused a significant reduction in visceral fat weight (p<0.05). Expression of PPARd increased in the exercise groups and was significantly increased in the highfat diet+exercise group (p<0.05). Among the ER stress-related proteins, the expression levels of p-PERK and CHOP, related to cardiac muscle damage, were significantly higher in the cardiac muscle of the high-fat diet group (p<0.05), and were significantly reduced by intermittent ladder-climbing exercise training (p<0.05). Specifically, this reduction was greater when the rats underwent exercise after switching back to the chow diet with a reduced caloric intake. Collectively, these results suggest that the combination of intermittent ladder-climbing exercise training and a reduced caloric intake can decrease the levels of ER stress-related proteins that contribute to cardiac muscle damage in obesity and aging. However, additional validation is required to understand the effects of these changes on mitochondrial biogenesis during exercise. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 12264512
- Volume :
- 21
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Korean Journal of Physiology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 126177135
- Full Text :
- https://doi.org/10.4196/kjpp.2017.21.6.633