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Concerning the vitamin D reference range: pre-analytical and analytical variability of vitamin D measurement.
Concerning the vitamin D reference range: pre-analytical and analytical variability of vitamin D measurement.
- Source :
-
Biochemia Medica . 2017, Vol. 27 Issue 3, p453-466. 14p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 2 Graphs. - Publication Year :
- 2017
-
Abstract
- Unlike other vitamins, the vitamin D concentration in blood varies cyclically over the course of the year in relation to genetic (gender, ethnicity, polymorphisms) and environmental factors (sunlight exposure, diet, food-related or direct vitamin D supplementation, skin pigmentation). Although the major diagnostics manufacturers have recently developed improved automated 25-hydroxy vitamin D immunoassays, the intra- and interlaboratory variability is still high (especially at low vitamin D concentrations) which might lead to incorrect vitamin D deficiency/insufficiency diagnosis. Moreover, despite recent efforts to standardize the assay and minimize its variability, the current bias for measured vitamin D concentrations is often still above the desirable ± 10% criterion. Because the implications of low vitamin D concentrations in non-skeletal diseases are still partially unknown, international guideline recommendations for establishing meaningful ranges, at any time over the course of the year, irrespective not only of environmental and personal factors but also of instrumental variability, are needed. In this review, we discuss the main factors that influence the variability of vitamin D concentrations and whether a centile curve, individually calculated by a theoretical equation considering such factors, might be better suited than a fixed limit to assess abnormal vitamin D concentrations in otherwise healthy subjects. Vitamin D reference ranges during pregnancy, childhood, or diagnosed illnesses, which merit separate discussion, are beyond the scope of this review. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13300962
- Volume :
- 27
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemia Medica
- Publication Type :
- Academic Journal
- Accession number :
- 126148631
- Full Text :
- https://doi.org/10.11613/BM.2017.030501