药物涂层球囊概述及其在外周动脉疾病治疗中的应用进展.

Percutaneous transluminal angioplasty (PTA) has been widely used in the treatment of peripheral arterial disease (PAD). However, there are some shortcomings in this technique, such as elastic recoil of the vessel wall and neointimal hyperplasia. Implantation with bare metal stent (BMS) after PTA can reduce the elastic recoil of the vessel wall, but in stent restenosis (ISR) has also become a prominent problemin the treatment. Drug eluting stents (DES) are used to resolve the problem of ISR, but late stent thrombosis (LST), delayed endothelialization, and long-term antiplatelet therapy are also associated with the treatment of DES. In this context, the drug coated balloon (DCB) has gained rapid development. As a non stent based treatment perscription, the DCB angioplasty can transfer the active drugs to the vascular wall of the diseased section, and have better therapeutic effects on ISR or de novo lesions. This paper briefly introduces the development history of DCB, and through laboratory research, animal experiments and clinical trials, to expound the coating technology, coating drugs, excipients and so on DCB efficacy and safety from the mechanism, and its application progress in the treatment of PAD. [ABSTRACT FROM AUTHOR]