[Cu(phen)(PPh)]NO-catalyzed microwave-assisted green synthesis of 5-substituted 1 H-tetrazoles.

An efficient synthetic methodology for construction of 5-substituted 1 H-tetrazoles under microwave irradiation in green medium is described. With [Cu(phen)(PPh)]NO as catalyst and HO-isopropyl alcohol (IPA) as reaction medium, various substituted nitriles underwent (3 + 2) cycloaddition reaction with NaN under microwave irradiation to provide corresponding 5-substituted 1 H-tetrazoles in high yield. This method is not only efficient and general but also benefits from high functional group tolerance. This environmentally friendly synthetic methodology is visualized as an alternative to existing procedures, providing a simple route to privileged scaffolds. Graphical Abstract: [ABSTRACT FROM AUTHOR]