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Syntheses, crystal structures, and Jack bean urease inhibitory activities of copper(II) complexes derived from 4- tert -butyl- N′ -(1-(pyridin-2-yl)ethylidene)benzohydrazide.
- Source :
-
Journal of Coordination Chemistry . Oct2017, Vol. 70 Issue 20, p3449-3458. 10p. - Publication Year :
- 2017
-
Abstract
- Two new copper(II) complexes, [CuL(HL)]·ClO4 (1) and [Cu2Br2L2]·0.85H2O (2), where L is the monoanionic form of 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL), have been prepared. The complexes were characterized by infrared and UV–vis spectra, and single crystal X-ray diffraction. Complex 1 is a mononuclear copper(II) species and 2 is a bromido-bridged dinuclear copper(II) species. The Cu ion in 1 is in an octahedral coordination mode and that in 2 is trigonal-bipyramidal. The Jack bean urease inhibitory assay indicated that 2 is active, with IC50 value of 20.6 ± 2.3 μmol L−1, while 1 is inactive. Molecular docking of 2 with Jack bean urease was studied. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00958972
- Volume :
- 70
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of Coordination Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 126037524
- Full Text :
- https://doi.org/10.1080/00958972.2017.1390569