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Nickel(II)-Catalyzed Site-Selective C-H Bond Trifluoromethylation of Arylamine in Water through a Coordinating Activation Strategy.
- Source :
-
Organic Letters . 10/20/2017, Vol. 19 Issue 20, p5661-5664. 4p. - Publication Year :
- 2017
-
Abstract
- The first example of nickel(II)-catalyzed site-selective C-H bond trifluoromethylation of arylamine in water is established. In this transformation, a coordinating activation strategy is performed by the utilization of picolinamide as a directing group, and target products are obtained in moderate to good yields. In addition, the catalyst-in-water system can be reutilized eight times with a slight loss of catalytic activity and applied in the green, concise synthesis of acid red 266. Furthermore, a series of control experiments verify that a single-electron transfer mechanism is responsible for this reaction. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NICKEL catalysts
*AROMATIC amines
*CARBON-hydrogen bonds
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 125949790
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b02823