Back to Search Start Over

One-Pot Multicomponent Synthesis of Glycopolymers through a Combination of Host-Guest Interaction, Thiol-ene, and Copper-Catalyzed Click Reaction in Water.

Authors :
Hu, Xiang
Gao, Jinbo
Luo, Yan
Wei, Ting
Dong, Yishi
Chen, Gaojian
Chen, Hong
Source :
Macromolecular Rapid Communications. Oct2017, Vol. 38 Issue 20, pn/a-N.PAG. 8p.
Publication Year :
2017

Abstract

There is a common phenomenon that the heterogeneity of natural oligosaccharides contains various sugar units, which can be used to enhance affinity and selectivity toward a specific receptor, so the synthesis of heterogeneous glycopolymers is always an important issue in the glycopolymer field. Herein, this study conducts a one-pot method to prepare polyrotaxane-based heteroglycopolymers anchored with different sugar units and fluorescent moieties via the combination of host-guest interaction, thiol-ene, and copper-catalyzed click chemistry in water. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, X-ray diffraction, and Ellman's assay test are used in the paper to characterize the compounds. Quartz crystal microbalance-dissipation (QCD-D) experiments and bacterial adhesion assay are utilized to study the interactions of polyrotaxane-based heteroglycopolymers with Con A and Escherichia coli. The results reveal that polyrotaxanes (PRs) with mannose and glucose present better specificity toward Con A and E. coli than PRs with glucose due to synergistic effects. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10221336
Volume :
38
Issue :
20
Database :
Academic Search Index
Journal :
Macromolecular Rapid Communications
Publication Type :
Academic Journal
Accession number :
125744292
Full Text :
https://doi.org/10.1002/marc.201700434