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One-Pot Multicomponent Synthesis of Glycopolymers through a Combination of Host-Guest Interaction, Thiol-ene, and Copper-Catalyzed Click Reaction in Water.
- Source :
-
Macromolecular Rapid Communications . Oct2017, Vol. 38 Issue 20, pn/a-N.PAG. 8p. - Publication Year :
- 2017
-
Abstract
- There is a common phenomenon that the heterogeneity of natural oligosaccharides contains various sugar units, which can be used to enhance affinity and selectivity toward a specific receptor, so the synthesis of heterogeneous glycopolymers is always an important issue in the glycopolymer field. Herein, this study conducts a one-pot method to prepare polyrotaxane-based heteroglycopolymers anchored with different sugar units and fluorescent moieties via the combination of host-guest interaction, thiol-ene, and copper-catalyzed click chemistry in water. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, X-ray diffraction, and Ellman's assay test are used in the paper to characterize the compounds. Quartz crystal microbalance-dissipation (QCD-D) experiments and bacterial adhesion assay are utilized to study the interactions of polyrotaxane-based heteroglycopolymers with Con A and Escherichia coli. The results reveal that polyrotaxanes (PRs) with mannose and glucose present better specificity toward Con A and E. coli than PRs with glucose due to synergistic effects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10221336
- Volume :
- 38
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Macromolecular Rapid Communications
- Publication Type :
- Academic Journal
- Accession number :
- 125744292
- Full Text :
- https://doi.org/10.1002/marc.201700434