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Circulating resistin levels and risk of multiple myeloma in three prospective cohorts.
- Source :
-
British Journal of Cancer . 10/10/2017, Vol. 117 Issue 8, p1241-1245. 5p. 3 Charts. - Publication Year :
- 2017
-
Abstract
- Background:Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case-control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, this association has not been investigated prospectively.Methods:We measured resistin concentrations for pre-diagnosis peripheral blood samples from 178 MM cases and 358 individually matched controls from three cohorts participating in the MM cohort consortium.Results:In overall analyses, higher resistin levels were weakly associated with reduced MM risk. For men, we observed a statistically significant inverse association between resistin levels and MM (odds ratio, 0.44; 95% confidence interval (CI) 0.24-0.83 and 0.54; 95% CI 0.29-0.99, for the third and fourth quartiles, respectively, vs the lowest quartile; Ptrend=0.03). No association was observed for women.Conclusions:This study provides the first prospective evidence that low circulating resistin levels may be associated with an increased risk of MM, particularly for men. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 117
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 125598448
- Full Text :
- https://doi.org/10.1038/bjc.2017.282