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Evaluation of beta-cell function in diabetic Taiwanese children using a 6-min glucagon test.
- Source :
-
European Journal of Pediatrics . Jul2008, Vol. 167 Issue 7, p801-805. 5p. - Publication Year :
- 2008
-
Abstract
- This study evaluates the effects of glucagon 30 mug/kg (maximal 1 mg) on beta-cell function in children by C-peptide determined before and 6 min after intravenous administration. From 1990 to 2005, 118 Taiwanese children with newly diagnosed diabetes mellitus (98 children with type 1 and 20 children with type 2) and 29 normal Taiwanese children were enrolled in this study. Fasting and 6-min post-glucagon C-peptide levels were analyzed. In the pre-pubertal group, the median fasting serum C-peptide levels were 0.2 and 0.8 nmol/l in type 1 diabetes and normal children, respectively. These levels rose to 0.3 and 1.9 nmol/l after glucagon stimulation. In the pubertal group, the median fasting serum C-peptide levels were 0.3, 1.0 and 0.9 nmol/l in type 1 diabetes, type 2 diabetes and normal children, respectively. They rose to 0.4, 2.5 and 2.7 nmol/l after glucagon stimulation. Both fasting and post-glucagon C-peptide levels in type 1 diabetes patients were significantly lower than those of normal children and children with type 2 diabetes. The optimal cut-off values to distinguish type 1 diabetes patients from those with type 2 as determined by the receiving operating characteristic curve were 0.7 and 1.1 nmol/l, respectively. The sensitivities of both C-peptide values were 93%. The post-glucagon C-peptide level was more powerful in distinguishing type 1 diabetes from type 2 diabetes with higher specificity (95% vs. 85%). The 6-min glucagon test is valuable in assessing beta-cell function in children and can help pediatricians in the differential diagnoses of diabetes mellitus in children. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYPE 2 diabetes diagnosis
*C-peptide
*CLINICAL trials
*COMPARATIVE studies
*DIFFERENTIAL diagnosis
*GLUCAGON
*GLUCOSE tolerance tests
*GLYCOSYLATED hemoglobin
*ISLANDS of Langerhans
*TYPE 1 diabetes
*RESEARCH methodology
*MEDICAL cooperation
*TYPE 2 diabetes
*RESEARCH
*EVALUATION research
*RECEIVER operating characteristic curves
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 167
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 125519796
- Full Text :
- https://doi.org/10.1007/s00431-007-0594-9