Methotrexate-induced leukoencephalopathy presenting as stroke in the emergency department.

Key Clinical Message Methotrexate-induced leukoencephalopathy is to be considered as a potential etiology in any patient presenting with stroke-like symptoms after receiving methotrexate. One of our cases suggests that the method of administration of the methotrexate can be IV or intrathecal and still results in leukoencephalopathy. [ABSTRACT FROM AUTHOR]