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Total Synthesis of Crocagin A.
- Source :
-
Angewandte Chemie International Edition . 10/9/2017, Vol. 56 Issue 42, p12848-12851. 4p. - Publication Year :
- 2017
-
Abstract
- Crocagin A ( 1) combines an attractive molecular structure with an unusual biosynthesis and bioactivity. An efficient synthesis of crocagin A is presented that hinges on an early formation of the heterotricyclic core, an electrophilic amination, and the stereoselective hydrogenation of a tetrasubstituted double bond. This synthesis confirms the absolute configuration of crocagin A and provides access to the natural product and derivatives thereof for further biological testing. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 56
- Issue :
- 42
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 125483871
- Full Text :
- https://doi.org/10.1002/anie.201612641