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Chemical analysis and anti-proliferative activity of Campania Thymus Vulgaris essential oil.
- Source :
-
Journal of Essential Oil Research . Dec2017, Vol. 29 Issue 6, p461-470. 10p. - Publication Year :
- 2017
-
Abstract
- In this study, the potential antitumor activity of an essential oil (EO) obtained from Thymus vulgaris L. plants cultivated in Campania (Southern Italy) was evaluated. The gas chromatography-mass spectrometry and Fourier transform infrared spectroscopy were used to investigate the chemical composition of EO. The monoterpenes thymol, p-cymene and carvacrol are the more abundant compounds detected. The anti-proliferative activity of the EO as a function of dose and time of exposure was evaluated by MTT assay on human osteosarcoma U2OS and pancreatic cancer PANC-1 cell lines. EO inhibits proliferation of both cell lines, but the effect on PANC-1 cells was more extensive. Flow cytometry and Western blot analyses revealed that the anti-proliferative effect is due to a decrease of cells in the S phase and their accumulation in the G1 phase, associated with the decrease of cyclin A and the increase of cell cycle inhibitor p27 protein levels, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10412905
- Volume :
- 29
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Essential Oil Research
- Publication Type :
- Academic Journal
- Accession number :
- 125437881
- Full Text :
- https://doi.org/10.1080/10412905.2017.1351405