补肾温阳化瘀法对子宫内膜异位症患者子宫内膜腺上皮细胞OPN 与MMP-9 的影响.

Objective: To investigate the effects of bushen wenyang liuayu treatment on semm levels of endometrial glandular epithelial cells osteopontin (OPN) and matrix metalloproteinases-9 (MMP-9) in patients with endometriosis. Methods: 92 cases with endometriosis who were treated in our hospital from April 2013 to April 2016 were selected and randomly divided into the control group and the observation group with 46 cases in each group. The patients in the control group were treated with western medicine, while the patients in the observation group were treated with bushen wenyang huayu method. Then the serum levels of OPN. MMP-9. estradiol (E2). luteinizing hormone (LH). follicle-stimulating hormone (FSH). tumor necrosis factor-a (TNF-a). interleukin-6 (IL-6). interleukin-8 (IL-8). CD3+, CD4+. CDS" and CD47CD8L the clinical efficacy and safety in the two groups were observed and compared before and after the treatment. Results: After treatment, the serum levels of OPN. MMP-9. TNF-α. DL-6. IL-8 and CD8+ in the observation group were lower than those of the control group, while the levels of CD3+, CD4+ and CD47 CD8+ were higher, and the differences were statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the control group, while the incidence of adverse reactions was lower (P<0.05). Conclusion: Bushen wenyang huayu method can reduce the serum levels of OPN endometrial glandular epithelial cells and MPP-9 of patients with endometriosis. [ABSTRACT FROM AUTHOR]