Synthesis, crystal structure and biological activity of the Schiff base organotin(IV) complexes based on salicylaldehyde-o-aminophenol.

Schiff base organotin(IV) complexes C1 ∼ C5b have been synthesized via the reaction of the substituted salicylaldehyde- o -aminophenol Schiff base ligands ( L1 ∼ L3 ) with the dibenzyltin dichloride, n -butyltin trichloride or dibutyltin oxide, respectively. The complexes have been characterized by IR, UV–Vis, 1 H NMR, 13 C NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. The anticancer activity of the Schiff base ligand and complexes C1 ∼ C5b against five species of cancer cell which are Hela, MCF7, HepG2, Colo205, NCI H460 were tested respectively, the tests showed that C1 ∼ C5b exhibited significant anticancer activity for the cancer cells in comparison with the ligand, and the activity was greater than carboplatin. [ABSTRACT FROM AUTHOR]