Back to Search
Start Over
Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein.
- Source :
-
Antibodies (2073-4468) . Sep2017, Vol. 6 Issue 3, p11. 10p. - Publication Year :
- 2017
-
Abstract
- Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3--specific for the central repeat region--have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20734468
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Antibodies (2073-4468)
- Publication Type :
- Academic Journal
- Accession number :
- 125301970
- Full Text :
- https://doi.org/10.3390/antib6030011