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Maggot Antimicrobial Peptide Effect on TGF-β4 and TNF-α mRNA Expression in Small Intestinal Mucosa from Salmonella pullorum-Infected Chickens.
- Source :
-
Pakistan Veterinary Journal . 2017, Vol. 37 Issue 3, p281-286. 6p. - Publication Year :
- 2017
-
Abstract
- To explore the effects of maggot antimicrobial peptide treatment of Salmonella pullorum-infected chickens on the mRNA expression levels of TGF-β4 and TNF-α in small intestinal mucosa, the duodenum, jejunum and ileum mucosa were isolated 3, 5 and 7 days after induced AMP, non-induced AMP, antibiotics or maggot treatment and the TGF-β4 and TNF-α mRNA expression was evaluated by quantitative real-time PCR. We found that mRNA of TGF-β4 was highly expressed in the duodenum, jejunum, and ileum when Salmonella pulloruminfected chickens were treated with antibiotics, non-induced AMP, and AMP, respectively (P<0.001). Similarly, TNF-α mRNA was highly expressed in the duodenum and jejunum when Salmonella pullorum-infected chickens were treated with induced AMP and maggots, respectively (P<0.001), and the expression of TNF-α mRNA was higher in response to the use of induced AMP than antibiotics on day 5 after treatment (P<0.05). Therefore, maggot AMP functional efficiency, along with evaluation of TGF-β4 and TNF-α produced by small intestinal mucosa, may be useful for the prevention and treatment of Salmonella pullorum when developing new chicken feed additives. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MESSENGER RNA
*ANTIBIOTICS
*SALMONELLA
*ANTIMICROBIAL peptides
*INTESTINAL mucosa
Subjects
Details
- Language :
- English
- ISSN :
- 02538318
- Volume :
- 37
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Pakistan Veterinary Journal
- Publication Type :
- Academic Journal
- Accession number :
- 125257809