维生素E与左乙拉西坦对癫痫患者的临床疗效及血浆T-Aoc，MDA水平的影响.

Objective: To investigate the clinical effect of vitamin E (VE) and levetiracetam (LEV) on the epilepsy and serum levels of total antioxidant capacity (T-Aoc) and malondialdehyde (MDA) of patients. Methods: 134 cases with epilepsy who were treated in our hospital from June 2013 to September 2015 were selected and randomly divided into two groups. The patients in the control group were treated with LEV, while the patients in the observation group were treated with vitamin E on the basis of the control group. Then the clinical efficacy, the EEG background activity, plasma levels of T-Aoc and MDA of two groups were recorded and compared before and after the treatment, and the safety of treatment was also evaluated. Results: After the treatment, the total effective rate of observation group was 88.1%, which was higher than 74.6% in the control group (P<0.05). Compared with before treatment, the frequency of δ wave, and the θ wave of EEG in the two groups were increased, while the α wave frequency was decreased (P<0.05). After treatment, the improvement of EEG in the observation group was significantly better than that of the control group (P<0.05). Compared with before treatment, the plasma levels of T-Aoc in the observation group significantly increased, and the MDA decreased (P<0.01); In the control group, the plasma T-Aoc level slightly increased, and the MDA level slightly decreased, but the difference was not statistically significant (P>0. 05). Compared with control group, the improvement degree of oxidative stress indexes in the observation group were significantly better (P<0.01). The adverse reaction rate o f the observation group was 10.4%, which was higher than 7.5% in the control group, while there was no statistically significant difference (P>0.05). Conclusion: VE and LEV could effectively reduce the seizure frequency, improve the EEG background activity, balance oxidative/antioxidant system, and control recurrence in the treatment of in patients with epilepsy assisted treatment with high safety. [ABSTRACT FROM AUTHOR]