Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives.

The hepatoprotective and choleretic activities of three levopimaric acid derivatives were studied experimentally using a CCl-induced acute hepatitis model in rats. It was established that all investigated levopimaric acid derivatives tended to increase bile secretion whereas (5 R,9 R,13 S,18 S)-20-isopropyl-5,9-dimethyl-17-{[(4-methylphenyl)sulfonyl]imino}-14-oxopentacyclo[10.6.2.0.0.0]eicosa-15,19-diene-5-carboxylic acid ( I) and dimethyl (4b S,8 R)-2-isopropyl-3-4b,8-trimethyl-2,4-dioxo-4,4a,4b,5,6,7,8,8a,9,10-decahydro-3 H- spiro[3,10a-ethanophenanthrene-11,5-[1,3]thiazolidine]-8,12-dicarboxylate ( II) reduced transaminase enzyme levels in blood serum. [ABSTRACT FROM AUTHOR]