A smart approach for formulation process of escitalopram loaded bio-nano suspension for brain delivery via novelistic EAM (External acoustic meatus) platform.

Our aim was to target antidepressant drug loaded nano-suspension using novel bioexcepient isolated from kernels of Prunus amygdalus and explore the capability of external acoustic meatus as novel acoustic drug delivery system. We isolated the biomaterial and performed various physicochemical evaluations along with spectral analysis including UV, IR, Mass, NMR, SEM. The bio-nano suspension formulated with the novel bioexcepient was tested for its functional properties. Eight formulations of escitalopram were prepared by using biomaterial as a retardant cum stabilizer and glycerin as nanosizent. All formulations were subjected to various evaluations, including pH, dispersibility, entrapment efficiency, particle size, mucoadhesion, in vitro release and stability. Our results revealed that the biopolymer possess promising retardibility cum stability and mucoadhesivity. Based on the in vitro and pharmacodynamic results obtained, it can be concluded that significant amount of drug reaches to the brain via external acoustic meatus and so it is feasible to deliver antidepressant molecule by this novelistic route. [ABSTRACT FROM AUTHOR]