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Pneumococcal meningitis and endocarditis in an infant: possible improved survival with factor V Leiden mutation.
- Source :
-
European Journal of Pediatrics . Oct2017, Vol. 176 Issue 10, p1439-1442. 4p. - Publication Year :
- 2017
-
Abstract
- Streptococcus pneumoniae infections continue to remain associated with high morbidity and mortality. Although the incidence of invasive meningeal and/or lung disease are not uncommon, Streptococcus pneumoniae endocarditis is rare especially in healthy pediatric population. New studies have suggested a strong association between factor V leiden (FVL) mutation and favorable outcomes in critically ill children. A healthy 10 month old presented with sepsis and meningeal signs, was later confirmed to have Streptococcus pneumoniae meningitis and endocarditis. She was found to have factor V leiden mutation and made a complete recovery despite initial complications.<bold>Conclusion: </bold>Presence of factor V leiden mutation in critically ill children with severe septicaemia possibly contributes to better outcomes. What is known: • Mortality and morbidity remain high with invasive pneumococcal disease. • Pneumococcal endocarditis is rare in healthy pediatric population and results in significant morbidity and mortality What is new: • New studies have suggested a strong association between factor V leiden (FVL) mutation and favorable outcomes in critically ill children. • The presence of factor V mutation in children with extensive invasive pneumococcal disease possibly contributes to a better outcome. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INFECTIVE endocarditis
*STREPTOCOCCUS pneumoniae
*ENDOCARDITIS
*FACTOR V Leiden
*LUNG disease diagnosis
*CRITICALLY ill children
*GENETICS
*DISEASE risk factors
*BLOOD coagulation factors
*CATASTROPHIC illness
*GENETIC mutation
*PROGNOSIS
*GENETIC markers
*SEPSIS
*PNEUMOCOCCAL meningitis
*DIAGNOSIS
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 176
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 125187958
- Full Text :
- https://doi.org/10.1007/s00431-017-2973-1