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Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan.
- Source :
-
Virus Research . Aug2017, Vol. 240, p147-153. 7p. - Publication Year :
- 2017
-
Abstract
- Hepatitis E virus (HEV) causes acute or chronic hepatitis in humans and can be transmitted via the fecal-oral route. Pigs are one of the main reservoirs for this infection. Sixty pigs, 4–5 months of age, on a swine herd in Japan had detectable anti-HEV IgG antibodies, and five (8.3%) of them had ongoing infection of genotype 3 HEV. Five HEV strains obtained from the viremic pigs shared 98.8–100% nucleotide identity, and one representative strain (swHE1606845), whose entire genomic sequence was determined in this study, differed by 14.1–19.6% from the reported HEV strains of subtypes 3a–3k and by 14.7–19.1% from other genotype 3 HEV strains whose subtypes have not yet been assigned. swHE1606845 showed a higher nucleotide p-distance value of ≥0.143 with the genotype 3 HEV strains of subtypes 3a–3k and ≥0.152 with other genotype 3 strains of unassigned subtypes. A SimPlot analysis revealed a lack of recombination events. These results indicate that swHE1606845 is a candidate member of a novel subtype of genotype 3. Further efforts to identify the swHE1606845-like novel strain are warranted to clarify the origin of this strain and to determine the complete nucleotide sequences of two additional swHE1606845-like strains for assigning a new subtype. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS E virus
*HEPATITIS
*FECES
*MICROBIOLOGY
*IMMUNOGLOBULIN G
*VIRAL genomes
Subjects
Details
- Language :
- English
- ISSN :
- 01681702
- Volume :
- 240
- Database :
- Academic Search Index
- Journal :
- Virus Research
- Publication Type :
- Academic Journal
- Accession number :
- 125080626
- Full Text :
- https://doi.org/10.1016/j.virusres.2017.08.003