SPLENECTOMIA, METODĂ TERAPEUTICĂ ÎN ABORDAREA PACIENTULUI DIAGNOSTICAT CU LIMFOM MALIGN DE ZONĂ MARGINALĂ.

Marginal zone malignant lymphoma is a non-Hodgkin lymphoma, with B-cell proliferation, with indolent evolution, representing about 5-17% of all non-Hodgkin malignancies in adult patients. Etiologically, there is a constant association with chronic infections, but also with inflammation; in this case, chronic immune antigenic stimulation results in a lymphoid increase, from which the further oncological events occur, involving chromosomal abnormalities that activate intracellular signaling pathways, leading to antigen independent lymphoproliferation. The MALT subtype is the most common form of marginal zone non-Hodgkin lymphoma; in 50-70% of cases there is also an association with autoimmune disorders such as Hashimoto's thyroiditis, Wegener's granulomatosis, Sjögren's syndrome, and systemic lupus erythematosus. For diagnostic certainty of this type of lymphocytes, is required histopathological examination of spleen after surgical splenectomy or morphological/immunophenotype examination of circulating lymphocytes if there splenic lymphoma with villous lymphocytes. [ABSTRACT FROM AUTHOR]