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An extracorporeal carbon dioxide removal (ECCOR) device operating at hemodialysis blood flow rates.

Authors :
Jeffries, R.
Lund, Laura
Frankowski, Brian
Federspiel, William
Source :
Intensive Care Medicine Experimental. 9/6/2017, Vol. 5 Issue 1, p1-12. 12p.
Publication Year :
2017

Abstract

Background: Extracorporeal carbon dioxide removal (ECCOR) systems have gained clinical appeal as supplemental therapy in the treatment of acute and chronic respiratory injuries with low tidal volume or non-invasive ventilation. We have developed an ultra-low-flow ECCOR device (ULFED) capable of operating at blood flows comparable to renal hemodialysis (250 mL/min). Comparable operating conditions allow use of minimally invasive dialysis cannulation strategies with potential for direct integration to existing dialysis circuitry. Methods: A carbon dioxide (CO) removal device was fabricated with rotating impellers inside an annular hollow fiber membrane bundle to disrupt blood flow patterns and enhance gas exchange. In vitro gas exchange and hemolysis testing was conducted at hemodialysis blood flows (250 mL/min). Results: In vitro carbon dioxide removal rates up to 75 mL/min were achieved in blood at normocapnia (pCO = 45 mmHg). In vitro hemolysis (including cannula and blood pump) was comparable to a Medtronic Minimax oxygenator control loop using a time-of-therapy normalized index of hemolysis (0.19 ± 0.04 g/100 min versus 0.12 ± 0.01 g/100 min, p = 0.169). Conclusions: In vitro performance suggests a new ultra-low-flow extracorporeal CO removal device could be utilized for safe and effective CO removal at hemodialysis flow rates using simplified and minimally invasive connection strategies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2197425X
Volume :
5
Issue :
1
Database :
Academic Search Index
Journal :
Intensive Care Medicine Experimental
Publication Type :
Academic Journal
Accession number :
125010825
Full Text :
https://doi.org/10.1186/s40635-017-0154-1