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Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis.
- Source :
-
Organic Letters . Sep2017, Vol. 19 Issue 17, p4580-4583. 4p. - Publication Year :
- 2017
-
Abstract
- Phainanolide A (1), a highly modified triterpenoid incorporating an unprecedented 6/9/6 heterotricyclic system and a highly oxygenated 5,5-spirocyclic ketal lactone, along with three new triterpenoids 2-4 were isolated from Phyllanthus hainanensis. Their structures were completely elucidated by a combination of diverse methods including 2D NMR, quantum chemical NMR and ECD calculations, and NMR data analogy with model compounds. Compounds 1-4 exhibited both remarkable cytotoxic and immunosuppressive activities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EUPHORBIACEAE
*TRITERPENOIDS
*TERPENES
*PHYLLANTHUS
*LANOSTEROL
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 124966660
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b02181