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Robust Antibody and Cytokine Response to Hepatitis B Vaccine Among Not-in-Treatment Patients With Chronic Hepatitis C: An Open-Label Control Study in China.
- Source :
-
Journal of Infectious Diseases . Aug2017, Vol. 216 Issue 3, p327-335. 9p. - Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Hepatitis B vaccine is an effective measure to prevent hepatitis B virus infection. Whether chronic hepatitis C virus (HCV) infection decreases humoral and cell-mediated immunity responses to hepatitis B vaccination is still controversial.<bold>Methods: </bold>Patients with chronic HCV infection who were not in treatment and healthy controls, matched at a 1:2 ratio for community, sex, and age (within 5 years), were identified from a community-based screening. All participants received 3 doses of hepatitis B vaccine. Antibody to hepatitis B surface antigen was tested 1 month after the third vaccine dose and was compared between 2 groups. Spot-forming cells (SFCs) of interferon γ and interleukin 2, 4, 5, and 6 were counted by means of enzyme-linked immunospot, and SFC counts were compared between the 2 groups.<bold>Results: </bold>The rates of nonresponse and low, normal, and high response were 3.80%, 10.13%, 45.57%, and 40.50% respectively, in the HCV group, and the corresponding rates in the healthy control group were 1.26%, 10.13%, 39.24%, and 49.37% (all P > .05). There were no significant differences in SFC counts between the 2 groups for interferon γ or interleukin 2, 4, or 5 (all P > .05).<bold>Conclusions: </bold>This study provided preliminary evidence of the good immunogenicity and safety of hepatitis B vaccination among patients in China with chronic hepatitis C who are not in treatment.<bold>Clinical Trials Registration: </bold>NCT 02898922. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHRONIC hepatitis C
*HEPATITIS B vaccines
*PHYSIOLOGICAL effects of cytokines
*IMMUNOGLOBULINS
*IMMUNOREGULATION
*PUBLIC health
*VACCINES
*THERAPEUTICS
*HEPATITIS B prevention
*CELLULAR immunity
*CLINICAL trials
*COMPARATIVE studies
*CYTOKINES
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*VIRAL antibodies
*VIRAL antigens
*LOGISTIC regression analysis
*EVALUATION research
*CASE-control method
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 216
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 124825559
- Full Text :
- https://doi.org/10.1093/infdis/jix295