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MECHANISM OF REAPPEARANCE OF CONTACT SENSITIVITY TO DNCB IN DESENSITIZED GUINEA PIGS.
- Source :
-
Journal of Investigative Dermatology . Jan1976, Vol. 66 Issue 1, p38-43. 6p. - Publication Year :
- 1976
-
Abstract
- The different immunologic activities of lymph node and spleen cells as compared to peritoneal exudate cells were studied in temporarily desensitized, DNCB-contact-sensitive guinea pigs. Lymph node (and spleen) lymphocytes: (a) transfer contact sensitivity to syngeneic recipients when harvested at the time of unresponsiveness; (b) are only temporarily inactivated in tolerant recipients by the desensitizing procedure; (c) enter the lymph node (or spleen) compartments in a higher proportion than peritoneal exudate cells; (d) are not susceptible to inactivation in vitro; and (e) are not permanently desensitized when released into the circulation by an intravenous injection of <em>Bordetella pertussis</em> vaccine. These results indicate that the resistance of primed lymph node cells to the desensitizing procedure may account for the reappearance of contact sensitivity in desensitized guinea pigs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022202X
- Volume :
- 66
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 12478082
- Full Text :
- https://doi.org/10.1111/1523-1747.ep12478082