Prediction of acute hypotensive episodes using EMD, statistical method and multi GP.

Acute hypotensive episodes (AHE) is a critical event in the ICU as it can cause multiple organ failure and thus has severe implications on the mortality risk. Timely and rapid intervention is necessary to save a patient's life. For the sake of this purpose, this paper presents a methodology to predict AHE for ICU patients based on mean arterial pressure time series. First, the empirical mode decomposition method is used to calculate complex MAP series. Then the original and intrinsic mode functions of MAP series are transformed for the feature extraction with the methods of probabilistic distribution and statistics. Finally, the multi genetic programming is presented to build the classification models for the prediction of AHE. The methodology is applied to the dataset from Multi-parameter intelligent monitoring for intensive care. The achieved accuracy of the proposed methodology is 82.92 % in the training set and 79.93 % in the testing set with the sixfold cross-validation in the total 2866 patient's records. Simulation results revealed the reasonable forecasting accuracy in prediction of AHE in 1 h forecasting window. [ABSTRACT FROM AUTHOR]