Susceptibilidad antimicrobiana de los aislamientos de Fusarium solani provenientes de onicomicosis.

BACKGROUND: Onychomycosis caused by F. solani are difficult to treat since this fungus presents high levels of resistance against commonly prescribed antifungal agents. OBJECTIVE: To evaluate the in vitro activity of itraconazole, terbinafine, ciclopirox and amorolfine against clinical isolates of F. solani. MATERIAL AND METHOD: A study was done in which the in vitro susceptibility of 29 clinical isolates of F. solani was determined using the microdilution method M38-A, as described by the Clinical Laboratory Standards Institute. The final dilutions were: 0.03-16 μg/mL for itraconazole, 0.13-64 μg/mL for terbinafine and amorolfine and 0.06-32 μg/mL for ciclopirox. RESULTS: The MIC50 and MIC90 for itraconazole were ≥16 μg/mL and ≥16 μg/mL, for terbinafine ≥64 μg/mL and ≥64 μg/mL, for amorolfine 1.25 μg/mL and ≥64 μg/mL and for ciclopirox 16 μg/mL and 20 μg/mL, respectively. CONCLUSIONS: Amorolfine exhibited the highest antifungal activity against clinical isolates of F. solani. [ABSTRACT FROM AUTHOR]