The reciprocal calculation procedure for setting occupational exposure limits for hydrocarbon solvents: An update.

Hydrocarbon solvents are liquid hydrocarbon fractions, often with complex compositions. Due to the potential for human exposure, primarily to the more volatile solvents, substantial effort has been directed toward the development of occupational exposure recommendations. Because of the complex and variable nature of these substances, a proposed approach is to calculate occupational exposure levels (OELs) using an adaptation of the mixture formula developed by the ACGIH® in which “group guidance values” are assigned to similar constituents. This approach is supported by the results of toxicological studies of hydrocarbon solvents and their constituents which have shown that, with a few well-characterized exceptions, these substances have similar toxicological properties and produce additive effects. The objective of the present document is to summarize recommended revisions to the earlier proposals; these recommendations take into account recent toxicological information and changes in regulatory advice. Practical demonstrations on how to use these recommendations to develop occupational exposure advice in different situations (from simple complex solvents to blends of complex solvents) are also provided. Finally, a quantitative ideal gas method is proposed as a means of calculating occupational exposure limits for solvent blends in which, because the blended components have differing vapor pressures, there may be substantial differences between the liquid and vapor phase compositions. [ABSTRACT FROM PUBLISHER]