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Environmental exposure to pesticides and the risk of Parkinson's disease in the Netherlands.

Authors :
Brouwer, Maartje
Huss, Anke
van der Mark, Marianne
Nijssen, Peter C.G.
Mulleners, Wim M.
Sas, Antonetta M.G.
van Laar, Teus
de Snoo, Geert R.
Kromhout, Hans
Vermeulen, Roel C.H.
Source :
Environment International. Oct2017, Vol. 107, p100-110. 11p.
Publication Year :
2017

Abstract

Background Exposure to pesticides has been linked to Parkinson's disease (PD), although associations between specific pesticides and PD have not been well studied. Residents of rural areas can be exposed through environmental drift and volatilization of agricultural pesticides. Objectives Our aim was to investigate the association between lifetime environmental exposure to individual pesticides and the risk of PD, in a national case-control study. Methods Environmental exposure to pesticides was estimated using a spatio-temporal model, based on agricultural crops around the residential address. Distance up to 100 m from the residence was considered most relevant, considering pesticide drift potential of application methods used in the Netherlands. Exposure estimates were generated for 157 pesticides, used during the study period, of which four (i.e. paraquat, maneb, lindane, benomyl) were considered a priori relevant for PD. Results A total of 352 PD cases and 607 hospital-based controls were included. No significant associations with PD were found for the a priori pesticides. In a hypothesis generating analysis, including 153 pesticides, increased risk of PD was found for 21 pesticides, mainly used on cereals and potatoes. Results were suggestive for an association between bulb cultivation and PD. Conclusions For paraquat, risk estimates for the highest cumulative exposure tertile were in line with previously reported elevated risks. Increased risk of PD was observed for exposure to (a cluster of) pesticides used on rotating crops. High correlations limited our ability to identify individual pesticides responsible for this association. This study provides some evidence for an association between environmental exposure to specific pesticides and the risk of PD, and generates new leads for further epidemiological and mechanistic research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01604120
Volume :
107
Database :
Academic Search Index
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
124611215
Full Text :
https://doi.org/10.1016/j.envint.2017.07.001