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Vaccination with Eimeria tenella elongation factor-1α recombinant protein induces protective immunity against E. tenella and E. maxima infections.
- Source :
-
Veterinary Parasitology . Aug2017, Vol. 243, p79-84. 6p. - Publication Year :
- 2017
-
Abstract
- Avian coccidiosis is caused by multiple species of the apicomplexan protozoan, Eimeria , and is one of the most economically devastating enteric diseases for the poultry industry worldwide. Host immunity to Eimeria infection, however, is relatively species-specific. The ability to immunize chickens against different species of Eimeria using a single vaccine will have a major beneficial impact on commercial poultry production. In this paper, we describe the molecular cloning, purification, and vaccination efficacy of a novel Eimeria vaccine candidate, elongation factor-1α (EF-1α). One day-old broiler chickens were given two subcutaneous immunizations one week apart with E. coli -expressed E. tenella recombinant (r)EF-1α protein and evaluated for protection against challenge infection with E. tenella or E. maxima . rEF-1α-vaccinated chickens exhibited increased body weight gains, decreased fecal oocyst output, and greater serum anti-EF-1α antibody levels following challenge infection with either E. tenella or E. maxima compared with unimmunized controls. Vaccination with EF-1α may represent a new approach to inducing cross-protective immunity against avian coccidiosis in the field. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03044017
- Volume :
- 243
- Database :
- Academic Search Index
- Journal :
- Veterinary Parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 124608519
- Full Text :
- https://doi.org/10.1016/j.vetpar.2017.06.003